Newborn Jaundice Technologies: Unbound Bilirubin and Bilirubin Binding Capacity in Neonates
نویسندگان
چکیده
منابع مشابه
Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice.
BACKGROUND The serum or plasma total bilirubin concentration (B(T)) has long been the standard clinical laboratory test for evaluating neonatal jaundice, despite studies showing that B(T) correlates poorly with acute bilirubin encephalopathy (ABE) and its sequelae including death, classical kernicterus, or bilirubin-induced neurological dysfunction (BIND). The poor correlation between B(T) and ...
متن کاملComparing transcutaneous bilirubin versus serum bilirubin measurement using spectrophotometry for jaundice screening of full-term neonates
Background: Neonatal jaundice is an almost common problem among neonates that may cause complications such as kernicterus in severe cases. Since early diagnosis and proper treatment of neonatal jaundice is vital to prevent the related complications, it is necessary to check bilirubin before discharging the neonates. There are several evaluating and diagnostic methods to measure the level of bil...
متن کاملReserve albumin binding capacity, salicylate saturation index, and red cell binding of bilirubin in neonatal jaundice.
Reserve albumin binding capacity, salicylate saturation index, and red cell binding of bili-rubin in neonatal jaundice. 105 blood samples from 72 infants, mostly with jaundice due to haemolytic disease, were analysed for reserve albumin binding capacity (HBABA method), salicylate saturation index (SI), and red cell binding of bilirubin. 2 infants with clinical symptoms of bilirubin encephalopat...
متن کاملA Comparison between Transcutaneous Bilirubin (TcB) and Total Serum Bilirubin (TSB) Measurements in Term Neonates
Background: Transcutaneous bilirubinometry (TCB) is a simple method for estimating bilirubin levels in neonates. This method is noninvasive, quick, and painless. We aimed to compare serum and cutaneous bilirubin measurements in term neonates.Method: In this descriptive cross-sectional study, 200 neonates with icter with birth weights of at least 2500 grams were studied. TCB was measured using a...
متن کاملUnbound bilirubin: a better predictor of kernicterus?
The peroxidase method described in this paper measures non–protein-bound bilirubin by oxidation of the free fraction. The oxidation rate is slow compared with rapid dissociation of albumin-bound bilirubin. Thus, the unbound bilirubin can be estimated from the initial rate of decline in total bilirubin concentration. In the 1970s, severe neonatal hyperbilirubinemia and kernicterus were major cli...
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ژورنال
عنوان ژورنال: Seminars in Perinatology
سال: 2011
ISSN: 0146-0005
DOI: 10.1053/j.semperi.2011.02.007